The paper intends to introduce main points of Eco’s critique of Vattimo’s philosophy. It focuses on differences in their approaches and provides a closer view of one of the philosophical discussions happening at the wake of the new millennium. We focus on understanding reality and the limits of interpretation as the two key points of Eco’s consideration and criticism. In 1983, Umberto Eco participated in publishing the well-known volume “weak thought”, although he later no longer considered himself part of the philosophical initiative. He represents a position of minimal or negative realism. Gianni Vattimo is a proponent of the “weak thought”, where reality is not introduced as stable, natural or objective. Reality does not itself speak out but needs a spokesmen or motivated interpreters. Vattimo, therefore revives Nietzsche’s thought “There are no facts, only interpretations”, which he deploys further in his own way.